He Yunjiao

Research Assistant Professor
School of Medicine
广东省深圳市南山区学苑大道1088号南方科技大学
heyj@sustech.edu.cn

SELF-INTRODUCTION:

Dr He is now the research assistant professor of School of medicine, South University of science and technology. She received the Ph.D. from Hong Kong University of technology in 2013, and then successively engaged in postdoctoral research at Hong Kong University of technology and South University of science and technology. Her main research fields are structural biology, carbohydrates biochemistry, etc.

 

EDUCATION:

1999-2003     Bachelor   Pharmacy          Wuhan University

2003-2006     Master    Medical Chemistry   Wuhan University

2009-2013     PhD      Structural Biology    The HongKong Polytechnic University

 

WOKRING EXPERIENCE:                

2006.07-2008.07    R&D chemist        Wuxi Apptech

2013.10-2014.07     Research Associate  The HongKong Polytechnic University

2014.07-2016.07     Postdoc fellow    The HongKong Polytechnic University

2016.09-2019.04    Postdoc fellow     Southern University of Science and Technology

2019.05-2020.04   Senior research scholar  Southern University of Science and Technology

2020.05-to now    Research assistant professor   Southern University of Science and Technology

 

PUBLICATIONS:

(1)   Shuai Wu # ,Yunjiao He#, Xianxiu Qiu,Wenchao Yang, Wenchao Liu, Xiaohua Li, Yan Li,Han-Ming Shen,Renxiao Wang, Zhenyu Yue, YanxiangZhao*. Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking. Proc Natl Acad Sci , 2018 Jun 19;115(25):E5669-E5678. (Co-first author)

(2)   Pan, Xuehua#; He, Yunjiao#; Chen, Tianfeng; Chan, Kin-Fai; Zhao, Yanxiang*, Modified Penicillin Molecule with Carbapenem- Like Stereochemistry Specifically Inhibits Class C beta-Lactamases. Antimicrobial Agents and Chemotherapy, 2017.12, 61(12). (Co-first author)

(3)   Pan, Xuehua; He, Yunjiao; Lei, Jinping; Huang, Xuhui; Zhao, Yanxiang*,Crystallographic Snapshots of Class A beta-Lactamase Catalysis Reveal Structural Changes That Facilitate beta-Lactam Hydrolysis. Journal of Biological Chemistry, 2017.3, 292(10): 4022~4033.

(4)   Pan, Xuehua; Wong, Wai-Ting; He, Yunjiao; Jiang, Yongwen; Zhao, Yanxiang*. Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation Biochemistry, 2014.8.26, 53(33): 5414~5423.

(5)   Teng H.; He Yunjiao.; Wu L.; Su J.; Feng X.; Qiu G.; Liang S.; Hu X*.  A general and facile synthetic approach to N-alpha-Boc ureidoalanine derivatives. Synlett, 2006, (6): 877~880.

(6) He Y, Lei J, Pan X, Huang X and Zhao Y. “Novel intermediates in the active site of Class A β-lactamase reveal critical factors that coordinate the catalytic water molecule for nucleophilic attack on β-lactam acyl adduct”. Scientific reports, 2019(Accepted)


Patents:

(1)   Patent: 20061001876. Xianming Hu, Hanbing Teng, Yunjiao He. A Facile Synthetic Approach to Na-Boc Ureidoalanine Derivatives.

(2)   Patent number:201710790073.9,Xuehua Pan,Yunjiao He,Jianhui chen, Yanxiang Zhao, Preparation and Application of Class C β - lactamase inhibitors.

(3)   United States Patent Application 20180002381, Zhao, Yanxiang, WU, Shuai , Yang, Wenchao, HE, Yunjiao, LI, Xiaohua, Qiu, Xianxiu, Hydrocarbon-stapled polypeptides for enhancement of endosome-lysosomal degradation.