Liu Xiaoyu

Research Assistant Professor
0755-88015583
广东省深圳市南山区学苑大道1088号南方科技大学
liuxy9@sustech.edu.cn

Personal Profile

Ph.D. in Biomedicine from The Chinese University of Hong Kong. He has previously worked at Shenzhen BGI Research Institute, School of Biomedicine, The Chinese University of Hong Kong, and Medical School of Jiangnan University. Since October 2019, he has been a research assistant professor in the School of Medicine of Southern University of Science and Technology. Engaged in the research of tumor cell cycle, apoptosis and autophagy mechanism. Published in SCI magazines such as Autophagy (2014), Cell Death & Disease (2019), Biochim Biophys Acta Mol Basis Dis (2018), Biochem Pharmacol (2019), etc 7 research papers.

 

Research areas

Engaged in the study of the mechanism of tumor cell cycle, apoptosis and autophagy. The molecular mechanism of cell carcinogenesis was studied from the perspective of Ca2+ steady state regulation, and the functions of Ca2+-related proteins in tumor cell proliferation, metastasis, autophagy and cell cycle regulation were analyzed.

 

Publications-Journal Papers

  • Liu X, Zhang P, Xie CM, et al. Activation of PTEN by inhibition of TRPV4 suppresses colon cancerdevelopment [J]. Cell death and disease, 2019Jun 12;10(6):460 .
  • Liu X, Wang T, Wang Y, et al. Orai1 is critical for Notch-driven aggressiveness under hypoxic conditions in triple-negative breast cancers[J].Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2018, 1864(4): 975-986.
  • Liu X, Wan X, Kan H, et al. Hypoxia-induced upregulation of Orai1 drives colon cancer invasiveness and angiogenesis[J]. European journal of pharmacology, 2018, 832: 1-10 .
  • Liu X, Han X, Wan X, et al. SPZ1 is critical for chemoresistance and aggressiveness in drug-resistant breast cancer cells[J]. Biochemical pharmacology, 2018, 156: 43-51.
  • Zhang P*, Liu X*, Li H, Chen Z, Yao X, Jin J, Ma X. TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway. Scientific Reports. 2017 Jun 9;7(1):3158. (* Co-first author)
  • Xie CM*, Liu XY*, Sham KW, Lai JM, Cheng CH. Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells. Autophagy. 2014; 10:0-13 (* Co-first author)
  • Qing Chao*, Xiao-Yu Liu*, Ying-Chang Mei, Zhi-Fang Gao, Yi-Bo Chen, Chun-Rong Qian, Yu-Bo Hao, Bai-Chen Wang. Light-regulated phosphorylation of maize phosphoenolpyruvate carboxykinase plays a vital role in its activity. Plant Mol Biol. 2014; 85: 95-105 (* Co-first author)
  • Xie CM, Liu XY, Yu S, Cheng CH. Cardiac glycosides block cancer growth through HIF-1α and NF-κB mediated Plk1. Carcinogenesis. 2013; 34:1870-80.
  • Liu XY, Wu YD, Shen ZY, Shen Z, Li HH, Yu XM, Yan XF, Guo CH, Wang BC. Shotgun proteomics analysis on maize chloroplast thylakoid membrane. Front Biosci. 2011; 3: 250-5.