LIU,Xiaoyu

Professor research assistant
医学院
0755-88015583
广东省深圳市南山区学苑大道1088号南方科技大学
liuxy9@sustech.edu.cn

Research area:


She is engaged in the research of tumor cell cycle, apoptosis and autophagy. This paper mainly studies the molecular mechanism of cell carcinogenesis from the perspective of Ca2 + homeostasis, and analyzes the functions of Ca2 + related proteins in tumor cell proliferation, metastasis, cell autophagy and cell cycle regulation.



学术成果:


1. Liu X, Zhang P, Xie CM, et al. Activation of PTEN by inhibition of TRPV4 suppresses colon cancerdevelopment [J]. Cell death and disease, 2019Jun 12;10(6):460 .

1.Liu X, Wang T, Wang Y, et al. Orai1 is critical for Notch-driven aggressiveness under hypoxic conditions in triple-negative breast cancers[J].Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2018, 1864(4): 975-986.

2.Liu X, Wan X, Kan H, et al. Hypoxia-induced upregulation of Orai1 drives colon cancer invasiveness and angiogenesis[J]. European journal of pharmacology, 2018, 832: 1-10 .

3. Liu X, Han X, Wan X, et al. SPZ1 is critical for chemoresistance and aggressiveness in drug-resistant breast cancer cells[J]. Biochemical pharmacology, 2018, 156: 43-51.

4. Zhang P*, Liu X*, Li H, Chen Z, Yao X, Jin J, Ma X. TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway. Scientific Reports. 2017 Jun 9;7(1):3158. (* Co-first author)

5. Xie CM*, Liu XY*, Sham KW, Lai JM, Cheng CH. Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells. Autophagy. 2014; 10:0-13 (* Co-first author)

6. Qing Chao*, Xiao-Yu Liu*, Ying-Chang Mei, Zhi-Fang Gao, Yi-Bo Chen, Chun-Rong Qian, Yu-Bo Hao, Bai-Chen Wang. Light-regulated phosphorylation of maize phosphoenolpyruvate carboxykinase plays a vital role in its activity. Plant Mol Biol. 2014; 85: 95-105 (* Co-first author)

7. Xie CM, Liu XY, Yu S, Cheng CH. Cardiac glycosides block cancer growth through HIF-1α and NF-κB mediated Plk1. Carcinogenesis. 2013; 34:1870-80.

8. Liu XY, Wu YD, Shen ZY, Shen Z, Li HH, Yu XM, Yan XF, Guo CH, Wang BC. Shotgun proteomics analysis on maize chloroplast thylakoid membrane. Front Biosci. 2011; 3: 250-5.